Python's emphasis on code readability and programmer efficiency have led to its use in a wide range of applications. As well as web technologies (Zope, Django and Pylons) and content management systems (Plone and Silva), Python can be found in such diverse places as film studios (Industrial Light & Magic, Sony Pictures Imageworks, Disney, Pixar), Internet search engines (Google, Infoseek), and scientific computing (NASA, Los Alamos National Laboratory, Lawrence Livermore National Laboratory, Fermi).

Python is particularly dominant in the area of Open Source web frameworks. The Python-based Plone CMS won the Packt Publishing Award 2008 for 'Best Other Open Source CMS', a category for content management systems not based on PHP - beating out systems based on more 'mainstream' technologies such as Java and .NET.

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